Testosterone replacement therapy may cause higher than normal red blood cells, which may increase the risk of heart problems or blood clots. While rare, when these complications occur, they may be serious or even life-threatening.

Testosterone treatment may cause enlargement of the prostate, which may result in difficulty urinating or an increased risk of urinary tract infections. Testosterone supplementation may also decrease sperm production and decrease fertility.

Minor side effects of testosterone therapy include gynecomastia (development of increasing breast tissue in males), acne, and depression.

This list of side effects is not comprehensive. An FDA document fully describing the indications, risks, and benefits of testosterone replacement therapy with testosterone cypionate can be reviewed by clicking here.